Synchronous termination of replication of the two chromosomes is an evolutionary selected feature in Vibrionaceae

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Synchronous termination of replication of the two chromosomes is an evolutionary selected feature in Vibrionaceae

Vibrio cholerae, the causative agent of the cholera disease, is commonly used as a model organism for the study of bacteria with multipartite genomes. Its two chromosomes of different sizes initiate their DNA replication at distinct time points in the cell cycle and terminate in synchrony. In this study, the time-delayed start of Chr2 was verified in a synchronized cell population. This replica...

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Synchronous replication initiation of the two Vibrio cholerae chromosomes

The genome of Vibrio cholerae, the causative agent of cholera, is divided between two circular replicons. Genomic analysis has revealed that several other bacterial species have more than one chromosome. However, to date, the dynamics of chromosome replication in bacteria with more than one chromosome have not been investigated. As in V. cholerae chromosome II (1.07 Mb) is smaller than chromoso...

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ژورنال

عنوان ژورنال: PLOS Genetics

سال: 2018

ISSN: 1553-7404

DOI: 10.1371/journal.pgen.1007251